MOTS-c is a mitochondrial-derived peptide that has attracted significant attention in biochemical research due to its unique origin and involvement in metabolic signalling pathways.
Encoded within mitochondrial DNA, the peptide represents a distinct class of signalling molecules that link mitochondrial function with broader cellular processes.
Its role in metabolic regulation and cellular communication has made it an important focus in studies exploring energy balance and mitochondrial biology.
QUICK PEPTIDE OVERVIEW
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Property
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Information
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Peptide Name
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MOTS-c
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Full Name
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Mitochondrial Open Reading Frame of the 12S rRNA-c
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Peptide Type
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Mitochondrial-derived peptide
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Amino Acid Sequence
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16 amino acids
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Molecular Formula
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(Sequence-dependent)
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Molecular Weight
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~2174 g/mol
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Research Category
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Mitochondrial / Metabolic Research
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CHEMICAL PROPERTIES & MOLECULAR DATA
Understanding the molecular characteristics of MOTS-c is essential for researchers studying mitochondrial signalling and peptide biology.
MOTS-c is a short peptide consisting of 16 amino acids encoded by mitochondrial DNA. Its structure allows it to participate in intracellular signalling processes that link mitochondrial activity with nuclear gene expression.
Mitochondrial-derived peptides such as MOTS-c are of particular interest because they represent a communication pathway between mitochondria and other cellular systems.
Ongoing research continues to investigate how these peptides influence cellular homeostasis and metabolic regulation.
WHAT IS MOTS-c?
MOTS-c is a biologically derived peptide produced within mitochondria, identified during research into mitochondrial genetic expression and signalling molecules.
Its discovery highlighted the role of mitochondria not only as energy-producing organelles but also as regulators of cellular communication.
In laboratory settings, MOTS-c is studied for its involvement in metabolic processes and its interaction with cellular signalling pathways.
MECHANISM OF ACTION
In research environments, MOTS-c is investigated for its interaction with pathways involved in metabolism and cellular stress responses.
Studies suggest the peptide may influence processes associated with:
- metabolic regulation
- mitochondrial function
- cellular stress response pathways
- gene expression related to energy balance
These mechanisms are being explored to better understand how mitochondrial signals influence overall cellular activity.
AREAS OF SCIENTIFIC RESEARCH
Due to its unique origin and biological role, MOTS-c is studied across multiple areas of peptide and metabolic research.
Common research topics include:
- mitochondrial biology studies
- metabolic pathway regulation
- cellular energy homeostasis
- stress response signalling
- gene expression and cellular adaptation
These research areas continue to expand as scientists investigate mitochondrial-derived signalling molecules.
RECONSTITUTION OF MOTS-c
In laboratory settings, MOTS-c is typically supplied as a lyophilised (freeze-dried) peptide to maintain stability.
Before use, the peptide is reconstituted using a sterile research solvent to form a solution suitable for experimental applications.
The solvent is generally introduced slowly along the vial wall to allow gradual dissolution. Gentle handling is recommended, while excessive agitation is typically avoided to preserve peptide structure.
Accurate concentration calculations are performed prior to preparation to ensure consistency in research protocols.
STORAGE OF MOTS-c
Proper storage conditions are essential for maintaining peptide integrity.
Lyophilised MOTS-c is typically stored in cool, dry environments, often under refrigeration or freezing conditions to ensure long-term stability.
Protection from moisture, light exposure, and temperature fluctuations helps minimise degradation.
Once reconstituted, solutions are generally stored at low temperatures and handled in accordance with standard laboratory practices.
SUMMARY
MOTS-c is a mitochondrial-derived peptide that has become a key focus in research due to its role in metabolic signalling and cellular energy regulation.
Its unique origin within mitochondrial DNA and its involvement in cellular communication pathways make it an important subject in studies of metabolism, mitochondrial biology, and cellular adaptation.
As research progresses, MOTS-c continues to provide insight into the complex relationship between mitochondrial function and overall cellular health.
